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Date:         Fri, 5 Dec 2008 16:00:44 +0200
Reply-To:     Joe van Zwaren <[log in to unmask]>
Sender:       Optics Newsletter <[log in to unmask]>
From:         Joe van Zwaren <[log in to unmask]>
Subject:      OPTICS-L: TAU EE Seminar by Asher Peled, December 11,
              2008 at 15:00, Room 206, Wolfson Mech. Eng. Bldg.,
              Tel-Aviv Univ., (parking facing gate 14)
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From: Esther Zilka [log in to unmask] Shalom, Please find attached a seminar from the Dept. of Physical Electronics for your information and distribution (if relevant). Thank you, Esther*.* *The seminar will take place on Thursday December 11, 2008, at 15:00, Room 206, Faculty of Engineering - Wolfson Mechanical Eng. Bldg., Tel Aviv University* ** * * * * Dept. SEMINAR * * * * * *** *Monolithic interferometric laser bio-sensor based on rare-earth doped sol-gel tapered amplifying waveguides*** *Asher Peled*** PhD student under the supervision of: *Prof. Menachem Nathan and Prof. Shlomo Ruschin* The first integrated optics biosensor based on an interferometric waveguide laser was demonstrated. As a milestone towards the interferometric laser biosensor, I report on the first rare-earth doped sol-gel channel waveguide amplifier, and also such first laser. The devices were built of a tapered rib waveguide which was etched into a thin guiding layer of Nd doped Si-Ti or Si-Hf sol-gel. In both amplifier and laser, the CW pumping was coupled in via a monolithic grating coupler which was etched into the sol-gel waveguide. This grating also coupled out the lasing signal. Reflection gratings supported the feedback. Therefore, the amplifier and laser devices were fully monolithic. In order to combine the benefits of spectral interrogation of an emitting biosensor with the sensitivity of interferometric devices, we designed a novel interferometric laser biosensor. We also developed a combined photolithographic - biochemical process to enable the patterning of the sensor receptors (antibodies) exclusively to the sensing branch. This was done in order to maximize sensitivity and to enable an integral and inherent biological reference, within the sensor device. Finally, we developed a novel "dry" optical immunoassay, in which the laser biosensor is measured in a dry phase. Successful specific recognition of CRP (C-reactive protein) was demonstrated using the device. CRP is used as an indicator for cardiovascular seizures. The implementation of our device as a CRP sensor would allow rapid label-free in-situ diagnosis of these diseases. The sensor can be converted for sensing almost any other protein by changing the fixated antibodies respectively.
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